Lesson Structure

1.0     Objectives

1.1     Introductions

1.2     The SNAr mechanism

1.2.1  Evidence for Nucleophilic Aromatic Substitution (SNAr) mechanism:

1.3     The SN1 mechanism

1.3.1  Evidence for a unimolecular SN1 mechanism

1.4     The benzyne (arynes) mechanism

1.4.1  Benzyme (aryne) mechanism:

1.5     The SRN1 mechanism

1.5.1  Evidence for the SRN1 mechanism:

1.6     Effects of Reactivity & Structure, leaving group and attacking nucleophile

1.6.1 The effect of substrate structure:

1.6.2 The effect of the leaving group:

1.6.3 The effect of the attacking nucleophile:

1.7     Von Richter rearrangements

1.8     Sommelet-Hauser rearrangement

1.9     Smiles rearrangement

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