Lesson Structure

Pericyclic Reactions Part 1 (Electrocyclic Reactions)

1.0         Objectives

1.1         Introduction

1.2         Molecular orbital symmetry

1.3         Frontier orbitals of ethylene, 1,3-butadiene, 1,3,5-hexatriene and allyl system.

1.4         Classification of pericyclic reactions.

1.5         Woodward-Hoffmann correlation diagrams

1.5.1     Correlation diagram Electrocyclic reaction

1.5.2     Frontier Molecular Orbital (FMO) approach for electrocyclic reactions

1.5.3     Perturbation Molecular orbital (PMO) approach for electrocyclic reactions(H-M) Huckel-Mobius system

Pericyclic Reactions Part 2 (Cycloadditions and Sigmatropic Reactions)

2.0         Objectives

2.1         Introduction

2.2         Antarafacial and suprafacial additions

2.3         Cycloaddition in 4n π and [4n +2] π system

2.4         2+2 Cycloaddition Reaction

2.5         cheleotropic reactions

2.5.1     [2 + 2] Chelotropic cycloaddition

2.6         [1, 3]-dipolar cycloadditions

2.7         Sigmatropic reactions/rearrangement

2.7.1     Explanation of [1, 3] and [1, 5] sigmatropic shift

2.8         Sigmatropic shifts of alkyl group

2.9         Huckel- Mobius approach in sigmatropic rearrangement

2.10       [3,3] sigmatropic rearrangements Cope rearrangements

2.11       Claisen rearrangement

2.12       [5, 5] rearrangement reactions.

2.13       Aza-Cope rearrangements:

2.14       Fluxional tautomerism

2.15       Ene reaction

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